FEATURES

FAMILY

class-II aminoacyl-tRNA synthetase family

DESCRIPTION

Also known as SYTE_AERPE, thrS2. Freestanding tRNA editing subunit of threonine--tRNA ligase, the catalytic subunit is probably AC Q9YDW0. Deacylates (edits) mischarged L-seryl-tRNA(Thr) in trans; has no activity on correctly charged L-threonyl-tRNA(Thr) (PubMed:26113036). Probably does not aminoacylate tRNA(Thr) (By similarity). Deacylates correctly charged glycyl-tRNA(Gly), but not glycyl-tRNA(Gly)(2'-dA76) (the terminal 2'-OH of tRNA adenine 76 has been dehydroxylated) nor the 2'-fluoro tRNA derivative, strongly suggesting the editing function is catalyzed by the 2'-OH of A76 of tRNA(Thr) (PubMed:26113036). Probably interacts with its catalytic subunit (By similarity).

EXTERNAL LINKS

thrS2

Threonine--tRNA ligase editing subunit

thrS2

Molecular Synopsis