FEATURES

FAMILY

DESCRIPTION

Also known as SV2C_RAT, Sv2c. Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles., (Microbial infection) Receptor for C.botulinum neurotoxin type A (BoNT/A, botA); the toxin binds Sv2c via extracellular loop 4 (PubMed:16543415). Restores uptake of BoNT/A in rat cells that are deleted for SV2 receptor (PubMed:16543415, PubMed:18815274)., (Microbial infection) Possible receptor for C.botulinum neurotoxin type D (BoNT/D, botD); BoNT/D does not bind to extracellular loop 4 as do BoNT/A and BoNT/E (PubMed:21483489). Another group does not find a convincing interaction with SV2 (PubMed:21632541)., (Microbial infection) Receptor for C.botulinum neurotoxin type F (BoNT/F); binding requires glycosylation of Asn-573 (PubMed:19476346, PubMed:19650874). Interacts with SYT1 in a calcium-dependent manner.

EXTERNAL LINKS

Sv2c

Structural Ligandability

Domains Chains

Distribution