FEATURES

FAMILY

DESCRIPTION

Also known as P4H1_ARATH, P4H1. Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in proline-rich peptide sequences of plant glycoproteins and other proteins. Hydroxylates preferentially prolines in second positions in the -Pro-Pro-Gly-triplets. Hydroxyprolines are important constituent of many plant cell wall glycoproteins such as extensins, hydroxyproline-rich glycoproteins, lectins and arabinogalactan proteins. Can hydroxylate collagen-like peptides and hypoxia-inducible transcription factor peptides.

EXTERNAL LINKS

uniprot
enzyme classification

P4H1

Prolyl 4-hydroxylase 1

P4H1

Structural Ligandability

Domains Chains

Distribution