FEATURES

FAMILY

DESCRIPTION

Also known as TX9A_URTGR, TX9A. affects the ASIC3 channel (ACCN3) and produces analgesic effects. It produces a reversible inhibition effect on both the transient and the sustained current of human ASIC3 channels expressed in X.laevis oocytes. It completely blocks the transient component (IC(50)=10 uM) and partially (48%) inhibits the amplitude of the sustained component (IC(50)=1.44 uM). Using in vivo tests in mice, it reverses inflammatory and acid-induced pain., does not affect the ASIC3 channel. Does not cause lethality or paralysis of noble crayfish (A.astacus) at a dose of 1 mg/kg., does not affect the ASIC3 channel. Does not cause lethality or paralysis of noble crayfish (A.astacus) at a dose of 1 mg/kg.

EXTERNAL LINKS

TX9A

Mutations

Mutation(s) distribution

Mutations table