FEATURES

FAMILY

DESCRIPTION

Also known as RPV1_VITRO, RPV1. Disease resistance (R) protein that confers resistance to multiple powdery and downy mildew by promoting cell death (PubMed:24033846, PubMed:28008335). Acts as a NAD(+) hydrolase (NADase): in response to activation, catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR) and nicotinamide; NAD(+) cleavage triggering a defense system that promotes cell death (PubMed:31439792). Homodimer; homodimerization is required for NAD(+) hydrolase (NADase) activity.

EXTERNAL LINKS

uniprot
enzyme classification

RPV1

Disease resistance protein RPV1

RPV1

Molecular Synopsis