FEATURES

FAMILY

DESCRIPTION

Also known as O17J_CONGE, O17J. Mu-conotoxins block voltage-gated sodium channels (Nav). This toxin (GVIIJ(SSG)) blocks Nav1.1/SCN1A (Kd=11 nM), Nav1.2/SCN2A (Kd=11 nM), Nav1.3/SCN3A (Kd=15 nM), Nav1.4/SCN4A (Kd=4.7 nM), Nav1.6/SCN8A (Kd=360 nM) and Nav1.7/SCN9A (Kd=41 nM) (PubMed:24497506, PubMed:26039939). It binds the channel at the newly described site 8, which is composed by two surfaces whose one contains a non-disulfide-bonded cysteine (which is free to covalently bind the toxin Cys-71) (PubMed:24497506). It is noteworthy that coexpression of subunits beta-2 or beta-4 (but not beta-1 or beta-3) protects rNav1.1-1.7 against block by the toxin, since these subunits (thanks to their extracellular domain) covalently bind to the key cysteine of the channel, thus preventing the covalent binding of the toxin (PubMed:24497506, PubMed:25632083).

EXTERNAL LINKS

O17J

Mu-conotoxin GVIIJ

O17J

Molecular Synopsis