4AJW

3D Structure View

CAVITIES

STRUCTURE SETTINGS

LIGANDS

Chain 4AJW_A

Chain 4AJW_B

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GENERAL

TITLE

DISCOVERY AND OPTIMIZATION OF NEW BENZIMIDAZOLE- AND BENZOXAZOLE- PYRIMIDONE SELECTIVE PI3KBETA INHIBITORS FOR THE TREATMENT OF PHOSPHATASE AND TENSIN HOMOLOGUE (PTEN)-DEFICIENT CANCERS

DATE LAST MODIFIED

24 Apr 2019

RELEASE

16 May 2012

OBSOLETE

CLASSIFICATION

TRANSFERASE

EXPERIMENT TYPE

X-RAY DIFFRACTION

SPACE GROUP

P 1 21 1

RESOLUTION RANGE HIGH

2.8

RESOLUTION RANGE LOW

71.6

PUBMED ID

22524426

DOI

10.1021/JM300241B

PDBe

4AJW

LIGANDS

1543460

Chains

Structure Chain	Target Protein	Gene	Expression System	Organism	Synonims	Actions
	Q9UUB1	--	SPODOPTERA FRUGIPERDA	HOUSE MOUSE	PI3-KINASE SUBUNIT DELTA, PI3K-DELTA, PI3KDELTA, P ...
	Q9UUB1	--	SPODOPTERA FRUGIPERDA	HOUSE MOUSE	PI3-KINASE SUBUNIT DELTA, PI3K-DELTA, PI3KDELTA, P ...

NGL Viewer is used for the molecular visualization.

AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402