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GENERAL
TITLE
CRYSTAL STRUCTURES OF HUMAN MEK1 WITH CARBOXAMIDE-BASED ALLOSTERIC INHIBITOR XL518 (GDC-0973), OR RELATED ANALOGS.
DATE LAST MODIFIED
18 Jun 2014
RELEASE
19 Dec 2012
OBSOLETE
CLASSIFICATION
TRANSFERASE
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 61
RESOLUTION RANGE HIGH
2.5
RESOLUTION RANGE LOW
94.07
PUBMED ID
DOI
10.1021/ML300049D
PDBe
4AN2
Chains
| Structure Chain | Target Protein | Gene | Expression System | Organism | Synonims | Actions |
|---|---|---|---|---|---|---|
| Q9QR71 | -- | SPODOPTERA FRUGIPERDA | HUMAN | MAP KINASE KINASE 1, MAPKK 1, MKK1, ERK ACTIVATOR ... |
NGL Viewer is used for the molecular visualization.
- AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
- AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402