4DSN

3D Structure View

CAVITIES

STRUCTURE SETTINGS

LIGANDS

Chain 4DSN_A

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GENERAL

TITLE

SMALL-MOLECULE LIGANDS BIND TO A DISTINCT POCKET IN RAS AND INHIBIT SOS-MEDIATED NUCLEOTIDE EXCHANGE ACTIVITY

DATE LAST MODIFIED

6 Jun 2012

RELEASE

25 Apr 2012

OBSOLETE

CLASSIFICATION

HYDROLASE

EXPERIMENT TYPE

X-RAY DIFFRACTION

SPACE GROUP

H 3

RESOLUTION RANGE HIGH

2.03

RESOLUTION RANGE LOW

PUBMED ID

DOI

10.1073/PNAS.1116510109

PDBe

LIGANDS

Structure Chain	Target Protein	Gene	Expression System	Organism	Synonims	Actions
	P01116	KRAS, KRAS2, RASK2	ESCHERICHIA COLI	HUMAN	KRAS 4B, K-RAS 2, KI-RAS, C-K-RAS, C-KI-RAS, GTPAS ...	Mutations

NGL Viewer is used for the molecular visualization.

AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402