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GENERAL
TITLE
CRYSTAL STRUCTURE OF COMPOUND 16 BOUND TO MDM2(17-111), {(3R,5R,6S)-5- (3-CHLOROPHENYL)-6-(4-CHLOROPHENYL)-1-[(1S)-1-CYCLOPROPYL-2- (PYRROLIDIN-1-YLSULFONYL)ETHYL]-3-METHYL-2-OXOPIPERIDIN-3-YL}ACETIC ACID
DATE LAST MODIFIED
-
RELEASE
6 May 2015
OBSOLETE
CLASSIFICATION
LIGASE/LIGASE INHIBITOR
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 21 21 21
RESOLUTION RANGE HIGH
1.7
RESOLUTION RANGE LOW
50
PUBMED ID
DOI
10.1016/J.BMCL.2014.06.073
PDBe
4QOC
LIGANDS
Chains
| Structure Chain | Target Protein | Gene | Expression System | Organism | Synonims | Actions |
|---|---|---|---|---|---|---|
| Q00987 | MDM2 | ESCHERICHIA COLI | HUMAN | DOUBLE MINUTE 2 PROTEIN, HDM2, ONCOPROTEIN MDM2, P ... | Mutations | |
| P14174 | MDM2 | ESCHERICHIA COLI | HUMAN | DOUBLE MINUTE 2 PROTEIN, HDM2, ONCOPROTEIN MDM2, P ... | ||
| P01899 | MDM2 | ESCHERICHIA COLI | HUMAN | DOUBLE MINUTE 2 PROTEIN, HDM2, ONCOPROTEIN MDM2, P ... | ||
| P01899 | MDM2 | ESCHERICHIA COLI | HUMAN | DOUBLE MINUTE 2 PROTEIN, HDM2, ONCOPROTEIN MDM2, P ... | ||
| P14174 | MDM2 | ESCHERICHIA COLI | HUMAN | DOUBLE MINUTE 2 PROTEIN, HDM2, ONCOPROTEIN MDM2, P ... | ||
| P14174 | MDM2 | ESCHERICHIA COLI | HUMAN | DOUBLE MINUTE 2 PROTEIN, HDM2, ONCOPROTEIN MDM2, P ... |
NGL Viewer is used for the molecular visualization.
- AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
- AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402