4QVX

3D Structure View

CAVITIES

STRUCTURE SETTINGS

LIGANDS

Bioassembly 4QVX_1

Chain 4QVX_A

Chain 4QVX_B

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GENERAL

TITLE

DISCOVERY OF A POTENT AND SELECTIVE BCL-XL INHIBITOR THAT DEMONSTRATES THROMBOCYTOPENIA AND INHIBITS TUMOR GROWTH IN VIVO

DATE LAST MODIFIED

26 Jul 2017

RELEASE

22 Jul 2015

OBSOLETE

CLASSIFICATION

APOPTOSIS/INHIBITOR

EXPERIMENT TYPE

X-RAY DIFFRACTION

SPACE GROUP

C 2 2 21

RESOLUTION RANGE HIGH

2.1

RESOLUTION RANGE LOW

56.98

PUBMED ID

DOI

10.1021/ML5001867

PDBe

LIGANDS

Structure Chain	Target Protein	Gene	Expression System	Organism	Synonims	Actions
	Q07817	BCL2L1, BCL2L, BCLX	ESCHERICHIA COLI	HUMAN	BCL2-L-1, APOPTOSIS REGULATOR BCL-X	Mutations
	Q07817	BCL2L1, BCL2L, BCLX	ESCHERICHIA COLI	HUMAN	BCL2-L-1, APOPTOSIS REGULATOR BCL-X	Mutations

NGL Viewer is used for the molecular visualization.

AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402