4RAO

3D Structure View

CAVITIES

STRUCTURE SETTINGS

LIGANDS

Bioassembly 4RAO_1

Chain 4RAO_A

Chain 4RAO_B

Chain 4RAO_C

Chain 4RAO_D

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GENERAL

TITLE

AZA-ACYCLIC NUCLEOSIDE PHOSPHONATES CONTAINING A SECOND PHOSPHONATE GROUP AS INHIBITORS OF THE HUMAN, PLASMODIUM FALCIPARUM AND VIVAX 6- OXOPURINE PHOSPHORIBOSYLTRANSFERASES AND THEIR PRO-DRUGS AS ANTIMALARIAL AGENTS

DATE LAST MODIFIED

24 Jan 2018

RELEASE

7 Jan 2015

OBSOLETE

CLASSIFICATION

TRANSFERASE/TRANSFERASE INHIBITOR

EXPERIMENT TYPE

X-RAY DIFFRACTION

SPACE GROUP

P 21 21 21

RESOLUTION RANGE HIGH

1.87

RESOLUTION RANGE LOW

46.43

PUBMED ID

25494538

DOI

10.1021/JM501416T

PDBe

LIGANDS

2849112 , 2694373

Chains

Target Protein	Gene	Expression System	Organism	Synonims
O75592	HPRT1, HPRT	ESCHERICHIA COLI	HUMAN	HGPRT, HGPRTASE
O60701	HPRT1, HPRT	ESCHERICHIA COLI	HUMAN	HGPRT, HGPRTASE
O60701	HPRT1, HPRT	ESCHERICHIA COLI	HUMAN	HGPRT, HGPRTASE
O60701	HPRT1, HPRT	ESCHERICHIA COLI	HUMAN	HGPRT, HGPRTASE

NGL Viewer is used for the molecular visualization.

AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402