5HD7

3D Structure View

CAVITIES

STRUCTURE SETTINGS

LIGANDS

Chain 5HD7_A

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GENERAL

TITLE

DISSECTING THERAPEUTIC RESISTANCE TO ERK INHIBITION RAT MUTANT SCH772984 IN COMPLEX WITH (3R)-1-(2-OXO-2-{4-[4-(PYRIMIDIN-2-YL) PHENYL]PIPERAZIN-1-YL}ETHYL)-N-[3-(PYRIDIN-4-YL)-2H-INDAZOL-5- YL]PYRROLIDINE-3-CARBOXAMIDE

DATE LAST MODIFIED

22 Nov 2017

RELEASE

24 Feb 2016

OBSOLETE

CLASSIFICATION

TRANSFERASE/TRANSFERASE INHIBITOR

EXPERIMENT TYPE

X-RAY DIFFRACTION

SPACE GROUP

P 21 21 2

RESOLUTION RANGE HIGH

1.69

RESOLUTION RANGE LOW

28.03

PUBMED ID

26832798

DOI

10.1158/1535-7163.MCT-15-0172

PDBe

LIGANDS

2950550 , 2730972

Chains

Structure Chain	Target Protein	Gene	Expression System	Organism	Synonims	Actions
	P63086	MAPK1, ERK2, MAPK, PRKM1	ESCHERICHIA COLI	RAT	MAPK 1,ERT1,EXTRACELLULAR SIGNAL-REGULATED KINASE ...	Mutations

NGL Viewer is used for the molecular visualization.

AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402