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GENERAL
TITLE
EGFR (L858R, T790M, V948R) IN COMPLEX WITH 1-[(3R,4R)-3-[({2-[(1- METHYL-1H-PYRAZOL-4-YL)AMINO]-7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL}OXY) METHYL]-4-(TRIFLUOROMETHYL)PYRROLIDIN-1-YL]PROP-2-EN-1-ONE
DATE LAST MODIFIED
23 Mar 2016
RELEASE
3 Feb 2016
OBSOLETE
CLASSIFICATION
TRANSFERASE/TRANSFERASE INHIBITOR
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 21 21 21
RESOLUTION RANGE HIGH
2.15
RESOLUTION RANGE LOW
25
PUBMED ID
DOI
10.1021/ACS.JMEDCHEM.5B01633
PDBe
5HG9
Chains
| Structure Chain | Target Protein | Gene | Expression System | Organism | Synonims | Actions |
|---|---|---|---|---|---|---|
| P0A786 | EGFR, ERBB, ERBB1, HER1 | SPODOPTERA FRUGIPERDA | HUMAN | PROTO-ONCOGENE C-ERBB-1,RECEPTOR TYROSINE-PROTEIN ... |
NGL Viewer is used for the molecular visualization.
- AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
- AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402