5KE0

3D Structure View

CAVITIES

STRUCTURE SETTINGS

LIGANDS

Chain 5KE0_A

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GENERAL

TITLE

DISCOVERY OF 1-1H-PYRAZOLO 4,3-C PYRIDINE-6-YL UREA INHIBITORS OF EXTRACELLULAR SIGNAL REGULATED KINASE ERK FOR THE TREATMENT OF CANCERS

DATE LAST MODIFIED

22 Nov 2017

RELEASE

6 Jul 2016

OBSOLETE

CLASSIFICATION

TRANSFERASE/TRANSFERASE INHIBITOR

EXPERIMENT TYPE

X-RAY DIFFRACTION

SPACE GROUP

P 21 21 2

RESOLUTION RANGE HIGH

1.68

RESOLUTION RANGE LOW

62.92

PUBMED ID

DOI

10.1021/ACS.JMEDCHEM.6B00708

PDBe

LIGANDS

Structure Chain	Target Protein	Gene	Expression System	Organism	Synonims	Actions
	P63086	MAPK1, ERK2, MAPK, PRKM1	ESCHERICHIA COLI	RAT	MAPK 1,ERT1,EXTRACELLULAR SIGNAL-REGULATED KINASE ...	Mutations

NGL Viewer is used for the molecular visualization.

AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402