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3D Structure View

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GENERAL
TITLE
DISCOVERY OF A NOVEL CLASS OF HIGHLY POTENT INHIBITORS OF THE P53-MDM2 INTERACTION BY STRUCTURE-BASED DESIGN STARTING FROM A CONFORMATIONAL ARGUMENT
DATE LAST MODIFIED
21 Sept 2016
RELEASE
7 Sept 2016
OBSOLETE
CLASSIFICATION
CELL CYCLE
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 61 2 2
RESOLUTION RANGE HIGH
1.58
RESOLUTION RANGE LOW
20
PUBMED ID
DOI
10.1016/J.BMCL.2016.08.010

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonymsActions
Q00987 MDM2 ESCHERICHIA COLI HUMAN DOUBLE MINUTE 2 PROTEIN,HDM2,ONCOPROTEIN MDM2,P53-BINDINGPROTEIN MDM2 HUMAN
DOUBLE MINUTE 2 PROTEIN,HDM2,ONCOPROTEIN MDM2,P53- ...
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402