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TITLE
THE CO-STRUCTURE OF (R)-4-(6-(1-(CYCLOPROPYLSULFONYL)CYCLOPROPYL)-2- (1H-INDOL-4-YL)PYRIMIDIN-4-YL)-3-METHYLMORPHOLINE AND A RATIONALLY DESIGNED PI3K-ALPHA MUTANT THAT MIMICS ATR
EXPRESSION SYSTEM(S)
UNIDENTIFIED BACULOVIRUS ,
EXPERIMENT TYPE
X-RAY DIFFRACTION
ORGANISM(S)
HOMO SAPIENS ,
CLASSIFICATION
TRANSFERASE/SIGNALING PROTEIN/INHIBITOR
SPACE GROUP:
P 21 21 21
RESOLUTION RANGE HIGH:
2.5
RESOLUTION RANGE LOW:
48.52
DOI:
10.1016/J.JMB.2017.04.006
EM DATA RESOURCE:
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DATE DEPOSITED:
2017-01-20 00:00:00
DATE RELEASED:
2017-06-14 00:00:00
DATE REVISED:
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BIOLOGICAL ASSEMBLY:
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3D Structure - 5UK8

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5UK8_B
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Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonyms
5UK8_B P27986 PIK3R1, GRB1 UNIDENTIFIED BACULOVIRUS HUMAN PTDINS-3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLINOSITOL 3-KINASE 85 KDA REGULATORY SUBUNIT ALPHA,PTDINS-3-KINASE REGULATORY SUBUNIT P85-ALPHA
5UK8_A P42336 PIK3CA UNIDENTIFIED BACULOVIRUS HUMAN PTDINS-3-KINASE SUBUNIT ALPHA,PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE 110 KDA CATALYTIC SUBUNIT ALPHA,P110ALPHA,PHOSPHOINOSITIDE-3-KINASE CATALYTIC ALPHA POLYPEPTIDE,SERINE/THREONINE PROTEIN KINASE PIK3CAALPHA DESIGNED TO MIMIC ATR LIGAND BINDING PROPERTIES.