6EPM

3D Structure View

CAVITIES

STRUCTURE SETTINGS

LIGANDS

Bioassembly 6EPM_1

Chain 6EPM_R

Chain 6EPM_S

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GENERAL

TITLE

RAS GUANINE NUCLEOTIDE EXCHANGE FACTOR SOS1 (REM-CDC25) IN COMPLEX WITH KRAS(G12C) AND FRAGMENT SCREENING HIT F1

DATE LAST MODIFIED

20 Feb 2019

RELEASE

6 Feb 2019

OBSOLETE

CLASSIFICATION

SIGNALING PROTEIN

EXPERIMENT TYPE

X-RAY DIFFRACTION

SPACE GROUP

I 4 2 2

RESOLUTION RANGE HIGH

2.5

RESOLUTION RANGE LOW

48.6

PUBMED ID

DOI

10.1073/PNAS.1812963116

PDBe

LIGANDS

Structure Chain	Target Protein	Gene	Expression System	Organism	Synonims	Actions
	P62875	KRAS, KRAS2, RASK2	ESCHERICHIA COLI	HUMAN	K-RAS 2,KI-RAS,C-K-RAS,C-KI-RASIS A CLONING ARTIFA ...
	Q07889	SOS1	ESCHERICHIA COLI	HUMAN	SOS-1	Mutations

NGL Viewer is used for the molecular visualization.

AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402