6GDQ

3D Structure View

CAVITIES

STRUCTURE SETTINGS

LIGANDS

Chain 6GDQ_A

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GENERAL

TITLE

FRAGMENT-BASED DISCOVERY OF A HIGHLY POTENT, ORALLY BIOAVAILABLE INHIBITOR WHICH MODULATES THE PHOSPHORYLATION AND CATALYTIC ACTIVITY OF ERK1/2

DATE LAST MODIFIED

27 Jun 2018

RELEASE

30 May 2018

OBSOLETE

CLASSIFICATION

SIGNALING PROTEIN

EXPERIMENT TYPE

X-RAY DIFFRACTION

SPACE GROUP

P 1 21 1

RESOLUTION RANGE HIGH

1.86

RESOLUTION RANGE LOW

44.33

PUBMED ID

DOI

10.1021/ACS.JMEDCHEM.8B00421

PDBe

LIGANDS

Structure Chain	Target Protein	Gene	Expression System	Organism	Synonims	Actions
	P28482	MAPK1, ERK2, PRKM1, PRKM2	ESCHERICHIA COLI BL21(DE3)	HUMAN	MAPK 1,ERT1,EXTRACELLULAR SIGNAL-REGULATED KINASE ...	Mutations

NGL Viewer is used for the molecular visualization.

AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402