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3D Structure View

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GENERAL
TITLE
MOLECULAR BASIS FOR INHIBITION OF HUMAN GAMMA-SECRETASE BY SMALL MOLECULE
DATE LAST MODIFIED
3 Feb 2021
RELEASE
27 Jan 2021
OBSOLETE
CLASSIFICATION
MEMBRANE PROTEIN
EXPERIMENT TYPE
ELECTRON MICROSCOPY
SPACE GROUP
P 1
RESOLUTION RANGE HIGH
3
RESOLUTION RANGE LOW
3
PUBMED ID
DOI
10.1016/J.CELL.2020.11.049
PDBe
--

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonimsActions
Q92542 NCSTN, KIAA0253, UNQ1874/PRO4317 HOMO SAPIENS HUMAN -- Mutations
P49768 PSEN1, AD3, PS1, PSNL1 HOMO SAPIENS HUMAN
PS-1,PROTEIN S182
Mutations
Q96BI3 APH1A, PSF, CGI-78, UNQ579/PRO1141 HOMO SAPIENS HUMAN
APH-1A,APH-1ALPHA,PRESENILIN-STABILIZATION FACTOR
Mutations
Q9NZ42 PSENEN, PEN2, MDS033 HOMO SAPIENS HUMAN
PRESENILIN ENHANCER PROTEIN 2
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402