6PF8

3D Structure View

CAVITIES

STRUCTURE SETTINGS

LIGANDS

Bioassembly 6PF8_1

Bioassembly 6PF8_2

Bioassembly 6PF8_3

Chain 6PF8_A

Chain 6PF8_B

Chain 6PF8_C

Chain 6PF8_D

Chain 6PF8_E

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GENERAL

TITLE

CRYSTAL STRUCTURE OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS IN COMPLEX WITH NADPH, FDUMP AND 2-(4-((2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2, 3-D]PYRIMIDIN-5-YL)METHYL)BENZAMIDO)-4-CHLOROBENZOIC ACID

DATE LAST MODIFIED

18 Dec 2019

RELEASE

2 Oct 2019

OBSOLETE

CLASSIFICATION

TRANSFERASE/TRANSFERASE INHIBITOR

EXPERIMENT TYPE

X-RAY DIFFRACTION

SPACE GROUP

C 1 2 1

RESOLUTION RANGE HIGH

2.53

RESOLUTION RANGE LOW

PUBMED ID

31536894

DOI

10.1016/J.EJMECH.2019.111673

PDBe

6PF8

LIGANDS

490791 , 931919 , 2870830 , 1235456

Chains

Gene	Expression System	Organism	Synonims
CHUDEA4_4460	ESCHERICHIA COLI BL21(DE3)	CRYPTOSPORIDIUM HOMINIS	--
CHUDEA4_4460	ESCHERICHIA COLI BL21(DE3)	CRYPTOSPORIDIUM HOMINIS	--
CHUDEA4_4460	ESCHERICHIA COLI BL21(DE3)	CRYPTOSPORIDIUM HOMINIS	--
CHUDEA4_4460	ESCHERICHIA COLI BL21(DE3)	CRYPTOSPORIDIUM HOMINIS	--
CHUDEA4_4460	ESCHERICHIA COLI BL21(DE3)	CRYPTOSPORIDIUM HOMINIS	--

NGL Viewer is used for the molecular visualization.

AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402