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GENERAL
TITLE
FUMARATE HYDRATASE OF MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH FORMATE AND ALLOSTERIC MODULATOR N-(5-((3,4-DIHYDROISOQUINOLIN-2(1H)- YL)SULFONYL)-2-METHOXYPHENYL)-2-(4-OXO-3,4-DIHYDROPHTHALAZIN-1-YL) ACETAMIDE
DATE LAST MODIFIED
25 Dec 2019
RELEASE
25 Sept 2019
OBSOLETE
CLASSIFICATION
LYASE
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
C 1 2 1
RESOLUTION RANGE HIGH
1.85
RESOLUTION RANGE LOW
52.2
PUBMED ID
DOI
10.1021/ACS.JMEDCHEM.9B01203
LIGANDS

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonimsActions
P9WN93 FUM, FUMC, DSI35_09545, ERS007663_02818, ERS007679_02635, ESCHERICHIA COLI BL21(DE3) MYCOBACTERIUM TUBERCULOSIS
FUMARASE C,AEROBIC FUMARASE,IRON-INDEPENDENT FUMAR ...
Mutations
P9WN93 FUM, FUMC, DSI35_09545, ERS007663_02818, ERS007679_02635, ESCHERICHIA COLI BL21(DE3) MYCOBACTERIUM TUBERCULOSIS
FUMARASE C,AEROBIC FUMARASE,IRON-INDEPENDENT FUMAR ...
Mutations
P9WN93 FUM, FUMC, DSI35_09545, ERS007663_02818, ERS007679_02635, ESCHERICHIA COLI BL21(DE3) MYCOBACTERIUM TUBERCULOSIS
FUMARASE C,AEROBIC FUMARASE,IRON-INDEPENDENT FUMAR ...
Mutations
P9WN93 FUM, FUMC, DSI35_09545, ERS007663_02818, ERS007679_02635, ESCHERICHIA COLI BL21(DE3) MYCOBACTERIUM TUBERCULOSIS
FUMARASE C,AEROBIC FUMARASE,IRON-INDEPENDENT FUMAR ...
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402