6TPD

3D Structure View

CAVITIES

STRUCTURE SETTINGS

LIGANDS

Chain 6TPD_A

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GENERAL

TITLE

FRAGMENT-BASED DISCOVERY OF PYRAZOLOPYRIDONES AS JAK1 INHIBITORS WITH EXCELLENT SUBTYPE SELECTIVITY

DATE LAST MODIFIED

22 Jul 2020

RELEASE

10 Jun 2020

OBSOLETE

CLASSIFICATION

TRANSFERASE

EXPERIMENT TYPE

X-RAY DIFFRACTION

SPACE GROUP

C 1 2 1

RESOLUTION RANGE HIGH

1.99

RESOLUTION RANGE LOW

53.18

PUBMED ID

DOI

10.1021/ACS.JMEDCHEM.0C00359

PDBe

LIGANDS

Structure Chain	Target Protein	Gene	Expression System	Organism	Synonims	Actions
	P12482	JAK2	SPODOPTERA FRUGIPERDA	HUMAN	JANUS KINASE 2,JAK-2

NGL Viewer is used for the molecular visualization.

AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402