6TPF

3D Structure View

CAVITIES

STRUCTURE SETTINGS

LIGANDS

Chain 6TPF_A

Chain 6TPF_B

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GENERAL

TITLE

FRAGMENT-BASED DISCOVERY OF PYRAZOLOPYRIDONES AS JAK1 INHIBITORS WITH EXCELLENT SUBTYPE SELECTIVITY

DATE LAST MODIFIED

22 Jul 2020

RELEASE

10 Jun 2020

OBSOLETE

CLASSIFICATION

TRANSFERASE

EXPERIMENT TYPE

X-RAY DIFFRACTION

SPACE GROUP

P 1 21 1

RESOLUTION RANGE HIGH

2.31

RESOLUTION RANGE LOW

85.6

PUBMED ID

DOI

10.1021/ACS.JMEDCHEM.0C00359

PDBe

LIGANDS

Structure Chain	Target Protein	Gene	Expression System	Organism	Synonims	Actions
	Q48255	--	--	HUMAN	JANUS KINASE 1,JAK-1
	Q48255	--	--	HUMAN	JANUS KINASE 1,JAK-1

NGL Viewer is used for the molecular visualization.

AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402