6X4O

3D Structure View

CAVITIES

STRUCTURE SETTINGS

LIGANDS

Chain 6X4O_A

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GENERAL

TITLE

HUMAN CYCLOPHILIN A BOUND TO A SERIES OF ACYLCIC AND MACROCYCLIC INHIBITORS: (2R,5S,11S,14S,18E)-2,11-DIMETHYL-14-(PROPAN-2-YL)-3-OXA- 9,12,15,21,29-PENTAAZATETRACYCLO[18.5.3.1~5,9~.0~23,27~]NONACOSA- 1(26),18,20,22,24,27-HEXAENE-4,10,13,16-TETRONE (COMPOUND 21)

DATE LAST MODIFIED

26 Aug 2020

RELEASE

24 Jun 2020

OBSOLETE

CLASSIFICATION

ISOMERASE/ISOMERASE INHIBITOR

EXPERIMENT TYPE

X-RAY DIFFRACTION

SPACE GROUP

P 21 21 21

RESOLUTION RANGE HIGH

1.5

RESOLUTION RANGE LOW

33.84

PUBMED ID

32539379

DOI

10.1021/ACS.JCIM.0C00132

PDBe

6X4O

LIGANDS

788541

Chains

Structure Chain	Target Protein	Gene	Expression System	Organism	Synonims	Actions
	P62937	PPIA, CYPA	ESCHERICHIA COLI	HUMAN	PPIASE A,CYCLOPHILIN A,CYCLOSPORIN A-BINDING PROTE ...	Mutations

NGL Viewer is used for the molecular visualization.

AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402