7DY7

3D Structure View

CAVITIES

STRUCTURE SETTINGS

LIGANDS

Bioassembly 7DY7_1

Chain 7DY7_A

Chain 7DY7_B

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GENERAL

TITLE

DISCOVERY OF NOVEL SMALL-MOLECULE INHIBITORS OF PD-1/PD-L1 AXIS THAT PROMOTES PD-L1 INTERNALIZATION AND DEGRADATION

DATE LAST MODIFIED

27 Apr 2022

RELEASE

26 Jan 2022

OBSOLETE

CLASSIFICATION

IMMUNOSUPPRESSANT

EXPERIMENT TYPE

X-RAY DIFFRACTION

SPACE GROUP

C 1 2 1

RESOLUTION RANGE HIGH

2.42

RESOLUTION RANGE LOW

23.472

PUBMED ID

DOI

10.1021/ACS.JMEDCHEM.1C01682

PDBe

LIGANDS

Structure Chain	Target Protein	Gene	Expression System	Organism	Synonims	Actions
	Q9NZQ7	CD274, B7H1, PDCD1L1, PDCD1LG1, PDL1	ESCHERICHIA COLI	HUMAN	HPD-L1,B7 HOMOLOG 1,B7-H1	Mutations
	O14514	CD274, B7H1, PDCD1L1, PDCD1LG1, PDL1	ESCHERICHIA COLI	HUMAN	HPD-L1,B7 HOMOLOG 1,B7-H1

NGL Viewer is used for the molecular visualization.

AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402