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GENERAL
TITLE
CRYSTAL STRUCTURE OF KSR2:MEK1 IN COMPLEX WITH ANP-PNP, AND ALLOSTERIC MEK INHIBITOR SELUMETINIB
DATE LAST MODIFIED
30 Dec 2020
RELEASE
30 Sept 2020
OBSOLETE
CLASSIFICATION
TRANSFERASE/TRANSFERASE INHIBITOR
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 61 2 2
RESOLUTION RANGE HIGH
3.09
RESOLUTION RANGE LOW
50
PUBMED ID
DOI
10.1038/S41586-020-2760-4

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonimsActions
Q6VAB6 KSR2 SPODOPTERA FRUGIPERDA HUMAN
HKSR2
Mutations
Q02750 MAP2K1, MEK1, PRKMK1 SPODOPTERA FRUGIPERDA RABBIT
MAPKK 1,ERK ACTIVATOR KINASE 1,MAPK/ERK KINASE 1,M ...
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402