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GENERAL
TITLE
EGFR L858R/V948R IN COMPLEX WITH OSIMERTINIB AND ALLOSTERIC INHIBITOR JBJ-09-063
DATE LAST MODIFIED
18 May 2022
RELEASE
15 Sept 2021
OBSOLETE
CLASSIFICATION
TRANSFERASE/TRANSFERASE INHIBITOR
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 1
RESOLUTION RANGE HIGH
2.6
RESOLUTION RANGE LOW
73.79
PUBMED ID
-
DOI
10.1038/S41467-022-30258-Y
PDBe
7K1H
LIGANDS
,
728282
Chains
| Structure Chain | Target Protein | Gene | Expression System | Organism | Synonims | Actions |
|---|---|---|---|---|---|---|
| P29476 | EGFR, ERBB, ERBB1, HER1 | SPODOPTERA FRUGIPERDA | HUMAN | PROTO-ONCOGENE C-ERBB-1,RECEPTOR TYROSINE-PROTEIN ... | ||
| Q8NHZ8 | EGFR, ERBB, ERBB1, HER1 | SPODOPTERA FRUGIPERDA | HUMAN | PROTO-ONCOGENE C-ERBB-1,RECEPTOR TYROSINE-PROTEIN ... | ||
| Q8NHZ8 | EGFR, ERBB, ERBB1, HER1 | SPODOPTERA FRUGIPERDA | HUMAN | PROTO-ONCOGENE C-ERBB-1,RECEPTOR TYROSINE-PROTEIN ... | ||
| Q8NHZ8 | EGFR, ERBB, ERBB1, HER1 | SPODOPTERA FRUGIPERDA | HUMAN | PROTO-ONCOGENE C-ERBB-1,RECEPTOR TYROSINE-PROTEIN ... | ||
| Q8NHZ8 | EGFR, ERBB, ERBB1, HER1 | SPODOPTERA FRUGIPERDA | HUMAN | PROTO-ONCOGENE C-ERBB-1,RECEPTOR TYROSINE-PROTEIN ... | ||
| Q8NHZ8 | EGFR, ERBB, ERBB1, HER1 | SPODOPTERA FRUGIPERDA | HUMAN | PROTO-ONCOGENE C-ERBB-1,RECEPTOR TYROSINE-PROTEIN ... |
NGL Viewer is used for the molecular visualization.
- AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
- AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402