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GENERAL
TITLE
X-RAY STRUCTURE OF HDM2/CMR19 AT 1.45A: DISCOVERY, X-RAY STRUCTURE AND CPP-CONJUGATION ENABLED UPTAKE OF P53/MDM2 MACROCYCLIC PEPTIDE INHIBITORS
DATE LAST MODIFIED
2 Feb 2022
RELEASE
22 Sept 2021
OBSOLETE
CLASSIFICATION
LIGASE
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
C 1 2 1
RESOLUTION RANGE HIGH
1.45
RESOLUTION RANGE LOW
19.51
PUBMED ID
DOI
10.1039/D1CB00056J
PDBe
7NUS
Chains
| Structure Chain | Target Protein | Gene | Expression System | Organism | Synonims | Actions |
|---|---|---|---|---|---|---|
| Q9Y2J2 | MDM2 | ESCHERICHIA COLI BL21(DE3) | HUMAN | DOUBLE MINUTE 2 PROTEIN,HDM2,ONCOPROTEIN MDM2,RING ... | ||
| Q00987 | MDM2 | ESCHERICHIA COLI BL21(DE3) | HUMAN | DOUBLE MINUTE 2 PROTEIN,HDM2,ONCOPROTEIN MDM2,RING ... | Mutations | |
| Q56148 | MDM2 | ESCHERICHIA COLI BL21(DE3) | HUMAN | DOUBLE MINUTE 2 PROTEIN,HDM2,ONCOPROTEIN MDM2,RING ... | ||
| P04789 | -- | -- | SYNTHETIC CONSTRUCT | -- | ||
| -- | -- | SYNTHETIC CONSTRUCT | -- | |||
| P04789 | -- | -- | SYNTHETIC CONSTRUCT | -- |
NGL Viewer is used for the molecular visualization.
- AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
- AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402