FEATURES

FAMILY

DESCRIPTION

Also known as GPC1_BRANA, GPC1. Glycerophosphocholine acyltransferase (GPCAT) that utilizes acyl-CoA to acylate glycero-3-phosphocholine (GPC), forming lysophosphatidylcholine (LPC) (PubMed:27758859). Shows broad acyl specificities with a preference for 16:0-CoA, polyunsaturated acyl-CoA, and the hydroxylated ricinoleoyl-CoA (PubMed:27758859). Catalyzes also the acylation of glycero-3-phosphoethanolamine (GPE) with acyl-CoA (PubMed:27758859). In addition to acyl-CoA, GPCAT efficiently utilizes LPC and lysophosphatidylethanolamine (LPE) as acyl donors in the acylation of GPC (PubMed:27758859). Contributes to the maintenance of phosphatidylcholine (PC) homeostasis and might also have specific functions in acyl editing of PC, such as transferring acyl groups modified at the sn-2 position of PC to the sn-1 (PubMed:27758859).

EXTERNAL LINKS

GPC1

Glycerophosphocholine acyltransferase 1

GPC1

Molecular Synopsis