FEATURES

FAMILY

DESCRIPTION

Also known as ESYN_FUSOX, ESYN1, ESYN. Nonribosomal peptide synthetase that synthesizes enniatin by coupling three D-hydroxycarboxylic acids and three L-amino acids via amide and ester bonds in an alternating fashion (PubMed:25398283, PubMed:28955446, PubMed:28946884). Whereas ESYN1 can accept different amino acids as precursors (L-valine, L-isoleucine or L-leucine), only one species of D-hydroxycarboxylic acid can be found in natural enniatin isolates (D-hydroxyisovaleric acid, D-Hiv) (PubMed:25398283, PubMed:28955446). D-Hiv stems from L-valine deanimation by a valine aminotransferase to 2-keto-isovaleric acid (2-Kiv), which becomes subsequently reduced by a keto-isovaleric acid reductase (KivR) to D-Hiv (PubMed:25398283, PubMed:28955446, PubMed:28946884).

ESYN1

Structural Ligandability

Domains Chains

Distribution