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FEATURES

FAMILY

pectinacetylesterase family

DESCRIPTION

Also known as NOTU2_XENLA, notum2. Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleylation of WNT proteins. Serine palmitoleylation of WNT proteins is required for efficient binding to frizzled receptors.

Also known as NOTU2_XENLA, notum2. Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleylation of WNT proteins. Serine palmitoleyl ...

EXTERNAL LINKS

uniprot
enzyme classification

notum2

Palmitoleoyl-protein carboxylesterase notum2

Structural Ligandability

Domains Chains

Distribution

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