FEATURES

FAMILY

DESCRIPTION

Also known as CMD1_CHLRE, CMD1. Dioxygenase that catalyzes DNA modification by mediating the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-glyceryl-methylcytosine (5gmC) (PubMed:31043749, PubMed:33531488). Catalyzes the conjugation of a glyceryl moiety from L-ascorbate (vitamin C) to the methyl group of 5mC through a carbon-carbon bond (PubMed:31043749, PubMed:33531488). 5gmC DNA modification may be required during photosynthesis as an epigenetic mark that couteracts DNA methylation (PubMed:31043749).

EXTERNAL LINKS

uniprot
enzyme classification

CMD1

5-methylcytosine-modifying enzyme 1

CMD1

Molecular Synopsis