FEATURES

DESCRIPTION

Also known as SFMD_STRLA, sfmD. Heme-containing peroxygenase that mediates the hydroxylation of 3-methyl-L-tyrosine (3-Me-Tyr) into 3-hydroxy-5-methyl-L-tyrosine (3-OH-5-Me-Tyr) in biosynthesis of saframycin A, a potent antitumor antibiotic that belongs to the tetrahydroisoquinoline family. Involved in biosynthesis of 3-hydroxy-5-methyl-O-methyltyrosine (3-OH-5-Me-OMe-Tyr), a core structure of saframycin A.

EXTERNAL LINKS

uniprot
enzyme classification

sfmD

3-methyl-L-tyrosine peroxygenase

Mutations

Mutation(s) distribution

Mutations table

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