FEATURES

FAMILY

DESCRIPTION

Also known as ISCA_ECO45, iscA. Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system TrxA/TrxB. Homodimer; may form tetramers and higher multimers.

EXTERNAL LINKS

uniprot
enzyme classification

iscA

Iron-binding protein IscA

iscA

Structural Ligandability

Domains Chains

Distribution