FEATURES

FAMILY

DESCRIPTION

Also known as OCEF1_LEPLB, OCEF1. Antibacterial peptide that inhibits reference strains of both Gram-negative bacteria (E.coli, P.aeruginosa, E.cloacae, K.pneumoniae, and A.actinomycetemcomitans) and Gram-positive bacteria (S.aureus) with relatively low potencies (MIC=25-400 uM) (PubMed:28115922) (By similarity). Shows antifungal activity against C.lusitaniae (MIC=50.25 uM), but no activity against C.albicans (PubMed:28115922). In the presence of an alkaloid (bufotenine), inhibits cellular infection by the rabies virus (PubMed:26635873). The peptide shows very low hemolytic activity against rabbit erythrocytes (PubMed:28115922) (By similarity). The low amphipathicity of alpha-helices demonstrated by wheel projection as well as the low cationicity may explain the low antibacterial and hemolytic potencies (By similarity).

Also known as OCEF1_LEPLB, OCEF1. Antibacterial peptide that inhibits reference strains of both Gram-negative bacteria (E.coli, P.aeruginosa, E.cloacae, K.pneumoniae, and A.actinomycetemcomitans) ...

EXTERNAL LINKS

OCEF1

Mutations

Mutation(s) distribution

Mutations table