FEATURES

FAMILY

DESCRIPTION

Also known as NLRC5_MOUSE, Nlrc5. Probable regulator of the NF-kappa-B and type I interferon signaling pathways. May also regulate the type II interferon signaling pathway. Plays a role in homeostatic control of innate immunity and in antiviral defense mechanisms. Interacts with CHUK and IKBKB; prevents CHUK and IKBKB phosphorylation and inhibits their kinase activity. Interacts with DDX58 and IFIH1; blocks the interaction of MAVS to DDX58.

EXTERNAL LINKS

uniprot
enzyme classification

Nlrc5

Mutations

Mutation(s) distribution

Mutations table