FEATURES

FAMILY

DESCRIPTION

Also known as RHSA_DICD3, rhsA. Toxic component of a toxin-immunity protein module, which functions as a cellular contact-dependent growth inhibition (CDI) system. This protein may be a nuclease that is specifically inhibited by its cognate immunity protein RhsAI. Upon expression of the C-terminus (residues 1284-1434) in E.coli growth is inhibited, cells elongate, nucleoids condense and plasmid DNA is degraded; these effects are blocked specifically by cognate immunity protein RshIA. Cell contact is necessary for growth inhibition.

EXTERNAL LINKS

uniprot
enzyme classification

rhsA

Probable deoxyribonuclease RhsA

rhsA

Structural Ligandability

Domains Chains

Distribution