FEATURES

FAMILY

DESCRIPTION

Also known as DGKD_MOUSE, Dgkd. Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:17021016). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed:17021016). By controlling the levels of diacylglycerol, regulates for instance the PKC and EGF receptor signaling pathways and plays a crucial role during development (PubMed:17021016). May also regulate clathrin-dependent endocytosis (By similarity). Homooligomer. Monomer. Interacts with AP2A2; regulates clathrin-dependent endocytosis.

Dgkd

Structural Ligandability

Domains Chains

Distribution