FEATURES

FAMILY

inward rectifier-type potassium channel family

DESCRIPTION

Also known as KCJ12_CHICK, KCNJ12. Inward rectifying potassium channel that is activated by phosphatidylinositol 4, 5-bisphosphate and that probably participates in controlling the resting membrane potential in electrically excitable cells. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. The inward rectification is probably due to the blockage of outward current by cytoplasmic polyamines and/or magnesium ions. Homotetramer.

EXTERNAL LINKS

uniprot
enzyme classification

KCNJ12

ATP-sensitive inward rectifier potassium channel 12

Mutations

Mutation(s) distribution

Mutations table

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