FEATURES

FAMILY

DESCRIPTION

Also known as UL130_HCMVM, UL130. Plays a role in viral entry into host cells. Forms a pentameric complex at the surface of the viral envelope together with gH, gL, UL130 and UL131. This complex is required for entry in epithelial, endothelial and myeloid host cells (PubMed:23853586, PubMed:28783665, PubMed:17942555). Mechanistically, engages host receptor(s) including neurophilin 2/NRP2 to mediate infection (PubMed:30057110). Forms the envelope pentamer complex (PC) composed of gH, gL, UL128, UL130, and UL131A. The pentamer interacts with host NRP2.

EXTERNAL LINKS

uniprot
enzyme classification

UL130

Envelope glycoprotein UL130

UL130

Molecular Synopsis