FEATURES

DESCRIPTION

Also known as U131A_HCMVM, UL131A. Plays a role in viral entry into host cells. Forms a pentameric complex at the surface of the viral envelope together with gH, gL, UL130 and UL131. This complex is required for entry in epithelial, endothelial and myeloid host cells (PubMed:23853586, PubMed:17942555). Mechanistically, engages host receptor(s) including neurophilin 2/NRP2 to mediate infection (PubMed:30057110). Contributes to the formation of the complex between UL128, UL130 and gH-gL. Forms the envelope pentamer complex (PC) composed of gH, gL, UL128, UL130, and UL131A. The pentamer interacts with host NRP2 (PubMed:17942555, PubMed:28783665, PubMed:30057110). The interaction with gH is important for the formation of UL128, UL130, gH-gL complex (PubMed:16894182).

EXTERNAL LINKS

UL131A

Protein UL131A

UL131A

Molecular Synopsis