FEATURES

FAMILY

DESCRIPTION

Also known as AOXC_MOUSE, Aox3, Aoh1. Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide and phthalazine, as well as aldehydes, such as benzaldehyde, retinal and pyridoxal. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Is probably involved in the regulation of reactive oxygen species homeostasis. May be a prominent source of superoxide generation via the one-electron reduction of molecular oxygen. Also may catalyze nitric oxide (NO) production via the reduction of nitrite to NO with NADH or aldehyde as electron donor. Homodimer.

Also known as AOXC_MOUSE, Aox3, Aoh1. Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide and phthalazine, as well as aldehydes, such as b ...

EXTERNAL LINKS

uniprot
enzyme classification

Aox3

Aldehyde oxidase 3

Aox3

Molecular Synopsis