FEATURES

FAMILY

DESCRIPTION

Also known as WBPB_PSEAE, wbpB, wlbA. Plays a role in the biosynthesis of B-band O antigen for serotype O5. Catalyzes the NAD-dependent oxidation of UDP-N-acetylglucosaminuronic acid (UDP-D-GlcNAcA) to UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronic acid (UDP-3-oxo-D-GlcNAcA). Cannot use UDP-GlcNAc or UDP-GalNAc as the nucleotide sugar substrate, and can use only poorly UDP-D-glucuronic acid (UDP-GlcA). Undergoes an NAD(+) recycling mechanism using 2-oxoglutarate as an oxidant. Homotetramer.

EXTERNAL LINKS

uniprot
enzyme classification

wbpB

UDP-N-acetyl-2-amino-2-deoxy-D-glucuronate oxidase

wbpB

Molecular Synopsis