FEATURES

FAMILY

DESCRIPTION

Also known as EF2K_HUMAN, EEF2K. Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced. Monomer or homodimer (Probable). Interacts with Calmodulin/CALM1; this interaction is strictly required for phosphorylation activity (PubMed:11015200).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

EEF2K

Mutations

Mutation(s) distribution

Mutations table