FEATURES

FAMILY

DESCRIPTION

Also known as DEGS1_HUMAN, DEGS1, DES1, MLD. Has sphingolipid-delta-4-desaturase activity. Converts D-erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine) (PubMed:11937514, PubMed:30620337, PubMed:30620338). Catalyzes the equilibrium isomerization of retinols (By similarity). Interacts with RLBP1; the interaction increases synthesis of chromophore-precursors by DEGS1.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

DEGS1

Sphingolipid delta(4)-desaturase DES1

DEGS1

Molecular Synopsis