FEATURES

DESCRIPTION

Also known as NKRF_HUMAN, NKRF, ITBA4, NRF. Interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of certain NK-kappa-B responsive genes. Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity. Also involved in the regulation of IL-8 transcription. Interacts with NF-kappa-B. Interacts with XRN2 (PubMed:24462208).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

NKRF

NF-kappa-B-repressing factor

NKRF

Molecular Synopsis