FEATURES

FAMILY

DESCRIPTION

Also known as TRI18_HUMAN, MID1, FXY, RNF59, TRIM18, XPRF. Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination. Homodimer or heterodimer with MID2. Interacts with IGBP1. Interacts with TRIM16.

Also known as TRI18_HUMAN, MID1, FXY, RNF59, TRIM18, XPRF. Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subun ...

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

MID1

E3 ubiquitin-protein ligase Midline-1

MID1

Molecular Synopsis