FEATURES

FAMILY

DESCRIPTION

Also known as KCNN4_HUMAN, KCNN4, IK1, IKCA1, KCA4, SK4. Forms a voltage-independent potassium channel that is activated by intracellular calcium (PubMed:26148990). Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells (PubMed:17157250, PubMed:18796614). Plays a role in the late stages of EGF-induced macropinocytosis (PubMed:24591580). Heterotetramer of potassium channel proteins (Probable). Interacts with MTMR6.

Also known as KCNN4_HUMAN, KCNN4, IK1, IKCA1, KCA4, SK4. Forms a voltage-independent potassium channel that is activated by intracellular calcium (PubMed:26148990). Activation is followed by memb ...

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

KCNN4

Mutations

Mutation(s) distribution

Mutations table