FEATURES

FAMILY

DESCRIPTION

Also known as BRI1_ARATH, BRI1. Receptor with a dual specificity kinase activity acting on both serine/threonine- and tyrosine-containing substrates. Regulates, in response to brassinosteroid binding, a signaling cascade involved in plant development, including expression of light- and stress-regulated genes, promotion of cell elongation, normal leaf and chloroplast senescence, and flowering. Binds brassinolide, and less effectively castasterone, but not 2, 3, 22, 23-O-tetramethylbrassinolide or ecdysone. May be involved in a feedback regulation of brassinosteroid biosynthesis. Phosphorylates BRI1-associated receptor kinase 1 (BAK1), Transthyretin-Like protein (TTL) and SERK1 on 'Ser-299' and 'Thr-462' in vitro. May have a guanylyl cyclase activity (PubMed:10557222, PubMed:10938344, PubMed:17138891, PubMed:17520012, PubMed:18694562, PubMed:19124768). Phosphorylates BSK1, BSK2 and BSK3 in vitro (PubMed:18653891). Phosphorylates BSK1, BSK3, BSK5, BSK6, BSK8 AND BSK11 in vitro (PubMed:23496207). Monomer or homodimer in the plasma membrane. Heterodimer with BAK1 in the endosomes. Interacts with SERK1 and TTL in a kinase-dependent manner. Bind to SERK1 in a brassinolide-dependent manner (PubMed:23929946). Component of the SERK1 signaling complex, composed of KAPP, CDC48A, GRF6 or GRF7, SERK1, SERK2, SERK3/BAK1 and BRI1. Interacts with CDG1 (PubMed:21855796). No interactions with PSKR1 or CNGC17 (PubMed:26071421). Interacts with BIK1 (PubMed:23818580). Interacts with B'ALPHA, B'BETA, B'GAMMA and B'ETA (PubMed:26517938). Interacts with BSK1 and BSK3 (PubMed:18653891). Interacts with BSK5, BSK6 and BSK11 (PubMed:23496207).

EXTERNAL LINKS

BRI1

Protein BRASSINOSTEROID INSENSITIVE 1

BRI1

Molecular Synopsis